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BrownNet Logo.

Alastair F. Brown

(Al Brown)

"Web users ultimately want to get at data quickly and easily. They don't care as much about attractive sites and pretty design." Tim Berners-Lee



Print Publications

Brown, A.F. & Lackie, J.M. (1980). Fibronectin decreases neutrophil adhesion. Cell Biol. Int. Rep. 4 791.

Brown, A.F. (1981). Invasion of 3-dimensional collagen gels by neutrophil granulocytes in vitro. Cell Biol. Int. Rep. 5(A) 4.

Brown, A.F. & Lackie, J.M. (1981). Fibronectin and collagen inhibit cell-substratum adhesion of neutrophil granulocytes. Expl. Cell Res. 136 225-231.

Brown, A.F. (1982). Neutrophil granulocytes: adhesion and locomotion on collagen substrata and in collagen matrices. J. Cell Sci. 58 455-467.

Lackie, J.M. & Brown, A.F. (1982). Substratum adhesion and the movement of neutrophil leucocytes. In WHITE BLOOD CELLS. Morphology and rheology as related to function. (eds U. Bagge, G.V.R. Born & P. Gaehtens). Microcirculation Reviews 1 127-133.

Forrester, J.V., Lackie, J.M. & Brown, A.F. (1983). Neutrophil behaviour in the presence of protease inhibitors. J. Cell Sci. 59 213-230.

Lackie, J.M. & Brown, A.F. (1983). Adhesion and the locomotion of neutrophils on surfaces and in matrices. In LEUKOCYTE LOCOMOTION AND CHEMOTAXIS. (eds H.U. Keller & G.O. Till). Agents and Actions Supplements 12 73-88.

Brown, A.F. (1984). Neutrophil and monocyte behaviour in three-dimensional collagen matrices. Scanning Electron Microscopy 1984 II 747-754.

Boocock, C.A., Brown, A.F. & Dunn, G.A. (1985). A simple chamber for observing microscopic specimens in both top and side view. J. Microscopy 137 29-34.

Lackie, J.M., Urquhart, C.M., Brown, A.F. & Forrester, J.V. (1985). Studies on the locomotory behaviour and adhesive properties of mononuclear phagocytes from blood. Br. J. Haematol. 60 567-581.

Dunn, G.A. & Brown, A.F. (1986). Alignment of fibroblasts on grooved surfaces described by a simple geometric transformation. J. Cell Sci. 83 313-340.

Dunn, G.A. & Brown, A.F. (1987). A unified approach to analysing cell motility. J. Cell Sci. Suppl. 8 81-102.

Middleton, C.A., Brown, A.F., Brown, R.M. & Roberts, D.J.H. (1988). The shape of cultured epithelial cells does not depend on the integrity of their microtubules. J. Cell Sci. 91 337-346.

Brown, A.F., Dugina, V., Dunn, G.A. & Vasiliev, J.M. (1989). A quantitative analysis of alterations in the shape of cultured fibroblasts induced by tumour-promoting phorbol ester. Cell Biol. Int. Rep. 13 357-366.

Brown, A.F. & Dunn, G.A. (1989). Microinterferometry of the movement of dry matter in fibroblasts. J. Cell Sci. 92 379-389.

Middleton, C.A., Brown, A.F., Brown, R.M., Karavanova, I.D., Roberts, D.J.H. & Vasiliev, J.M. (1989). The polarization of fibroblasts in early primary cultures is independent of microtubule integrity. J. Cell Sci. 94 25-32.

King, C.A., Preston, T.M., Brown, A.F., & Dunn, G.A. (1990). Interference microscope techniques in studies of cell motility. J. Cell Biol. 111 128.

Dunn, G.A. & Brown, A.F. (1990). Quantifying cellular shape using moment invariants. In MODELING ANALYSIS AND SIMULATION OF BIOLOGICAL MOTION (eds W. Alt & G. Hoffman). Lecture Notes on Biomathematics. Springer-Verlag.

Brown, A.F. & Dunn, G.A. (1991). Microinterferometry and digital image analysis of fibroblasts. Binary 3 80-81.

Zicha, D., Dunn, G.A., & Brown, A.F. (1991). A new direct-viewing chemotaxis chamber. J. Cell Sci. 99 769-775.

Wright, A.F., Mansfield, D.C., Green, D.K., Mooney, K., Brown, A.F., Fossarello, M., Jeffrey, S., Patton, M.A., Tommerup, N., Riise, R., Schinzel, A., & Evans, H.J. (1993). The use of automated linkage analysis in genetic mapping of autosomal recessive retinitis pigmentosa (ARRP) and Bardet-Biedl syndrome genes. Am. J. Hum. Gen. 53 abstract 1106.

Mansfield, D.C., Brown, A.F., Green, D.K., Carothers, A.D., Morris, S.W., He, L., Evans, H.J., & Wright, A.F. (1994). Automation of Genetic Linkage Analysis using Fluorescent microsatellite markers. Genomics 24 225-233.

He, L., Mansfield, D.C., Brown, A.F., Green, D.K., Morris, S.W., St. Clair, D.M., Muir, W.J., MacLean, A. Wright, A.F., Blackwood, D.H.R. (1994). Automated linkage analysis in psychiatric disorders. Am. J. Med. Genetics (Neuropsychiatric Genetics) 60 192-198.

Brown, A., McKie, M., van Heyningen, V., & Prosser, J. (1998). The Human PAX6 Mutation Database. Nucleic Acids Research 26 259-264.

Brown, A., McKie, M. (2000). MuStaR(TM) and Other Software for Locus-Specific Mutation Databases. Human Mutation 15 76-85.

Cotton RG; 2006 Human Variome Project, Appelbe W, Auerbach AD, Becker K, Bodmer W, Boone DJ, Boulyjenkov V, Brahmachari S, Brody L, Brookes A, Brown AF, Byers P, Cantu JM, Cassiman JJ, Claustres M, Concannon P, Cotton RG, den Dunnen JT, Flicek P, Gibbs R, Hall J, Hasler J, Katz M, Kwok PY, Laradi S, Lindblom A, Maglott D, Marsh S, Masimirembwa CM, Minoshima S, de Ramirez AM, Pagon R, Ramesar R, Ravine D, Richards S, Rimoin D, Ring HZ, Scriver CR, Sherry S, Shimizu N, Stein L, Tadmouri GO, Taylor G, Watson M (2007). Recommendations of the 2006 Human Variome Project meeting. Nat Genet. 39(4) 433-6.

Gout AM, Martin NC, Brown AF, Ravine D (2007). PKDB: Polycystic Kidney Disease Mutation Database--a gene variant database for autosomal dominant polycystic kidney disease. Hum Mutat. 28(7) 654-9.

R.G.H. Cotton, A.D. Auerbach, A.F. Brown, P. Carrera, J. Christodoulou, M. Claustres, J. Compton, D.W. Cox, E. De Baere, J.T. den Dunnen, M. Greenbla tt, M. Fujiwara, P. Hilbert, A. Jani, H. Lehvaslaiho, D.W. Nebert, I. Verma, M. Vihinen, Members of the Human Genome Variation Society the Human Variome Proj ect Diagnostic Laboratory Working Group (2007) A structured simple form for ordering genetic tests is needed to ensure coupling of clinical detail (phenotype) with DNA variants (genotype) to ensure utility in publication and databases. Hum Mutat. 28(10) 931-932.

Cotton, R.G.H.; Auerbach, A.D.; Beckmann, J.S.; Blumenfeld, O.O.; Brookes, A.J.; Brown, A.F.; Carrera, P.; Cox, D.W.; Gottlieb, B.; Greenblatt, M.S.; Hilbert, P.; Lehvaslaiho, H.; Liang, P.; Marsh, S.; Nebert, D.W.; Povey, S.; Rossetti, S.; Scriver, C.R.; Summar, M.; Tolan, D.R.; Verma, L.C.; Vihinen, M. and den Dunnen, J.T. (2008) Recommendations for Locus-Specific databases and Their Curation. Human Mutation 29(1):2-5.

Shu, X., McDowall, E., Brown, A.F., Wright, A.F. (2008) The human retinitis pigmentosa GTPase regulator gene variant database. Human Mutation 29(5):605-608.

On-line Publications

Brown, A., Hanson, I., McKie, M., van Heyningen, V., & Prosser, J. (1999). The Human PAX6 Mutation Database. Nucleic Acids Res 27 ( (Link removed by publisher - no redirection)

McNoe, L., Brown, A., McKie, M., & Eccles, M. (1999). The Human PAX2 Mutation Database. Nucleic Acids Res 27 ( (Link removed by publisher - no redirection)

Software Releases

Tracer (1991): A suite of programs for morphometric analysis, for use with PCs and most digitizing tablets. MS-DOS. Was available from the UK Mirrors Archive (originally at Higher Education National Software Archive). (No longer available)

ALP (1994): Automated Linkage Pre-processor - a program for sizing microsatellite DNA fragments, testing for Mendelian Inheritance, and preparing data in "LINKAGE" format to locate disease genes on chromosomes. MS-Windows 3.1. (No longer available)

Winloga (1997): A firewall Dropsafe Logger. Windows 3.1. (No longer available)

Human PAX6 Mutation Database (1997): HTML/cgi/JavaScript web interface to Human PAX6 Mutation Database, providing new mutation submission, searching of database, and statistics view. (Moved to LOVD software)

Mutability (1997): Calculates how many point substitutions in a DNA sequence would result in Nonsense, Missense, or Neutral mutations. HTML/cgi/JavaScript web application. (No longer available).

MuStaRTM (1999): Generic Locus-Specific Mutation Database software. A PC-based application with HTML/cgi/JavaScript interface for web distribution of the database. No longer available - Recommend LOVD software